产品货号：
Z19601
中文名称：
Laminin gamma 1/LAMC1抗体
英文名称：
Anti-Laminin gamma 1/LAMC1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Laminin gamma 1/LAMC1 Antibody |
| 指标别名 | LAMB2;LAMC1;Laminin 1 subunit gamma;Laminin 10 subunit gamma;Laminin 11 subunit gamma;Laminin 2 subunit gamma;Laminin 3 subunit gamma;Laminin 4 subunit gamma;Laminin 6 subunit gamma;Laminin 7 subunit gamma;Laminin 8 subunit gamma;Laminin 9 subunit gamma;Laminin B2 chain;Laminin subunit gamma 1;S LAM gamma;S laminin subunit gamma |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | LAMC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human Laminin gamma 1(1566-1579aa KKQEAAIMDYNRDI),different from the related mouse sequence by one amino acid and rat sequence by three amino acids. |
| 实际分子量 | 150～200KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Laminin gamma1,Laminin subunit gamma-1,is a protein that in humans is encoded by the LAMC1 gene.Laminins,a family of extracellular matrix glycoproteins,are the major noncollagenous constituent of basement membranes.They have been implicated in a wide variety of biological processes including cell adhesion,differentiation,migration,signaling,neurite outgrowth and metastasis.Laminins are composed of 3 non identical chains:laminin alpha,beta and gamma(formerly A,B1,and B2,respectively) and they form a cruciform structure consisting of 3 short arms,each formed by a different chain,and a long arm composed of all 3 chains.Each laminin chain is a multidomain protein encoded by a distinct gene.Several isoforms of each chain have been described.Different alpha,beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery,i.e.alpha1beta1gamma1 heterotrimer is laminin 1.The biological functions of the different chains and trimer molecules are largely unknown,but some of the chains have been shown to differ with respect to their tissue distribution,presumably reflecting diverse functions in vivo.This gene encodes the gamma chain isoform laminin,gamma 1.The gamma 1 chain,formerly though to be a beta chain,contains structural domains similar to beta chains,however,lacks the short alpha region separating domains I and II.The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes.Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination,lacked basement membranes,indicating that laminin,gamma 1 chain is necessary for laminin heterotrimer assembly.It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA,that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs(5.5 and 7.5kb) seen on Northern analysis. |
| Uniprot ID | P11047 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | laminin,gamma 1(formerly LAMB2) |
| 蛋白名全称 | Laminin subunit gamma-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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